Sawada Yasufumi, Satoh Hiroki
Laboratory of Drug Informatics, Graduate School of Pharmaceutical Sciences, The University of Tokyo.
Nihon Rinsho. 2012 Jan;70(1):27-41.
For the appropriate use of psychotropic drugs, such as hypnotics, antidepressants and antipsychotics, knowledge of the pharmacokinetic characteristics and the interactions of these drugs are required. The mechanisms of drug interaction can be subdivided into pharmacokinetic interactions and pharmacodynamic interactions. Among the former, interactions involving inhibition or induction of cytochrome P450 (CYP) enzymes are clinically very important. If such interactions cause an increase of systemic exposure to psychotropic drugs, adverse effects are likely, while a decrease exposure may lead to treatment failure. In this article, we review drug interactions of psychotropic drugs from the viewpoints of clinical evidence, mechanism, and management.
为了合理使用精神药物，如催眠药、抗抑郁药和抗精神病药，需要了解这些药物的药代动力学特征及其相互作用。药物相互作用的机制可细分为药代动力学相互作用和药效学相互作用。在前者中，涉及细胞色素P450（CYP）酶抑制或诱导的相互作用在临床上非常重要。如果此类相互作用导致精神药物的全身暴露增加，则可能产生不良反应，而暴露减少可能导致治疗失败。在本文中，我们从临床证据、机制和管理的角度综述精神药物的药物相互作用。
