Kalash G R
Department of Psychiatry, Jamaica Hospital Medical Center, NY, USA.
Psychooncology. 1998 Jul-Aug;7(4):307-20. doi: 10.1002/(SICI)1099-1611(199807/08)7:4<307::AID-PON366>3.0.CO;2-3.
An overview of drug metabolism, with particular focus on the cytochrome p450 system, is provided in this review. To date, there has been a growing body of literature concerning the cytochrome p450 enzyme, drug-drug interactions and the role of psychotropic medications when co-administered with medications prescribed in the medically ill population. The article provides an ability to cross-reference commonly prescribed medications to their known involvement as substrates, inhibitors or inducers of p450 enzymes. This information will permit the clinician working in an oncologic setting to better predict potential interactions based on available in vitro and in vivo data and choose psychotropics analytically when confronted with a situation of polypharmacy. A knowledge of drug interactions will decrease the uncertainty in prescription of multidrug therapies and minimize the likelihood of diminished drug efficacy or toxic reactions.
本综述提供了药物代谢概述，特别关注细胞色素P450系统。迄今为止，关于细胞色素P450酶、药物相互作用以及精神药物与内科疾病患者所开药物联合使用时的作用的文献越来越多。本文提供了一种能力，可将常用药物与其作为P450酶底物、抑制剂或诱导剂的已知参与情况进行交叉参考。这些信息将使肿瘤学环境中的临床医生能够根据现有的体外和体内数据更好地预测潜在相互作用，并在面对多药治疗情况时明智地选择精神药物。了解药物相互作用将减少多药治疗处方中的不确定性，并将药物疗效降低或毒性反应的可能性降至最低。
