Harada Sohei
Department of Microbiology and Infectious Diseases, Toho University School of Medicine.
Nihon Rinsho. 2012 Feb;70(2):329-32.
A variety of genetic elements play key role in the dissemination of antimicrobial resistance genes among gram-negative bacteria. Transposons can transfer resistance genes intracellularly, while conjugative plasmids carrying resistance genes can move from one bacterial cell to another. Integrons are genetic elements that can collect several resistance genes in the form of gene cassettes. These genetic elements sometimes coexist and work cooperatively. For example, integrons, which is not mobile by themselves, can obtain an ability to transfer when they are incorporated into transposons. Recent reports suggest that integrative and conjugative elements, hybrid elements of conjugative plasmids and phages, also contribute to the dissemination of resistance genes among gram-negative bacteria.
多种遗传元件在革兰氏阴性菌之间抗菌药物耐药基因的传播中起关键作用。转座子可在细胞内转移耐药基因，而携带耐药基因的接合质粒可从一个细菌细胞转移至另一个细菌细胞。整合子是能够以基因盒的形式收集多个耐药基因的遗传元件。这些遗传元件有时共存并协同发挥作用。例如，自身不具有移动性的整合子，当它们整合到转座子中时可获得转移能力。最近的报告表明，整合性接合元件，即接合质粒和噬菌体的杂交元件，也有助于革兰氏阴性菌之间耐药基因的传播。
