Furuya M E, Lupi-Herrera E, Correa E, Quesada A, Barrios R, Sandoval J
Departamento Cardiopulmonar, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
Arch Inst Cardiol Mex. 1990 May-Jun;60(3):233-9.
Pulmonary pressure-flow curves, hemodynamic and blood gas parameters in West's zone II condition were obtained in nine isolated in situ left lower lobes (LLL) before (condition A), and after 15, 30 and 60 minutes of lobar gelfoam embolization (GE) (condition B) in order to know the natural history of this model. After GE a decrease in PaO2 and lobar O2 were noticed (p less than 0.05). Vascular conductance (p less than 0.001) and lobar blood flow decreased (p less than 0.05), accompanied by a significant increase in the inflow (p less than 0.01) and in the mean closing pressures (p less than 0.01). These parameters did not change during the time of observation at condition B. Nor the cardiac output or the minimal closing pressure changed in relation to condition A. LLL angiographic findings showed evidence of arterial occlusion and the pattern of obstruction was not homogeneous. Lobes histology showed occluded arteries of more than 300 micrometers of diameter. We concluded that in this canine model of increased pulmonary vascular resistance, pulmonary vascular conductance and mean closing pressure change, remain stable during 60 minutes after GE allowing us to know the natural history of the preparation. Condition than allow to perform and evaluate other interventions on lung vascular mechanics in the experimental setting of pulmonary embolization.
为了解该模型的自然病程，在9个离体原位左下叶（LLL）中获取了West II区状态下的肺压力-流量曲线、血流动力学和血气参数，分别在（A状态）栓塞前以及明胶海绵栓塞（GE）15、30和60分钟后（B状态）进行测量。GE后，观察到PaO2和肺叶O2下降（p<0.05）。血管传导率（p<0.001）和肺叶血流量下降（p<0.05），同时流入量（p<0.01）和平均闭合压显著增加（p<0.01）。在B状态的观察期间，这些参数未发生变化。与A状态相比，心输出量和最小闭合压也未改变。LLL血管造影结果显示有动脉闭塞的证据，且阻塞模式不均匀。肺叶组织学显示直径大于300微米的动脉闭塞。我们得出结论，在这个肺血管阻力增加的犬模型中，肺血管传导率和平均闭合压发生变化，在GE后60分钟内保持稳定，这使我们能够了解该制备模型的自然病程。这种状态允许在肺栓塞的实验环境中对肺血管力学进行其他干预并进行评估。
