Lupi Herrera E, Furuya M E, Ramírez J C, Maxwell R, Sandoval J
Departamento Cardiopulmonar, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.
Arch Inst Cardiol Mex. 1990 Jul-Aug;60(4):341-5.
After inducing an increase in pulmonary vascular resistance (Rp) in an isolated in situ lobe (LAIS) embolized with gelfoam (GE), the effect of dopamine infused at 12 mcg/kg/min in eight mongrel dogs was evaluated. We studied the rectilinear pressure-flow (QL/PL) relationship, the hemodynamic and blood gas before (condition A), 15 minutes later GE (condition B) and after dopamine infusion (condition C). After GE a decrease in QL and an increase in inflow (PL) and mean critical closing pressures (PLi) were noticed (p less than 0.01). Also decrease in pulmonary vascular conductance (1/Rp) was noted. At condition C a rise in QL and PL were noticed (p less than 0.01), but 1/Rp and PLi did not change. We concluded that dopamine in the LAIS with increased Rp at the used doses does not have vasoactive action for those vessels responsible for the phenomenons where flow resistance or mean critical closing pressure occurs.
在用明胶海绵（GE）栓塞的离体原位肺叶（LAIS）中诱导肺血管阻力（Rp）增加后，评估了8只杂种犬以12微克/千克/分钟的速度输注多巴胺的效果。我们研究了直线压力-流量（QL/PL）关系、在GE前（A状态）、GE后15分钟（B状态）和多巴胺输注后（C状态）的血流动力学和血气情况。GE后，观察到QL降低，流入量（PL）和平均临界关闭压（PLi）增加（p<0.01）。还注意到肺血管传导率（1/Rp）降低。在C状态下，观察到QL和PL升高（p<0.01），但1/Rp和PLi没有变化。我们得出结论，在所使用的剂量下，多巴胺对LAIS中Rp增加且出现血流阻力或平均临界关闭压现象的血管没有血管活性作用。
