不同血糖指数饮食对健康个体血清胃动素、食欲素和神经肽 Y 浓度的急性影响。

Acute effects of different glycemic index diets on serum motilin, orexin and neuropeptide Y concentrations in healthy individuals.

机构信息

Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, China.

出版信息

Neuropeptides. 2012 Jun;46(3):113-8. doi: 10.1016/j.npep.2012.02.001. Epub 2012 Mar 11.

DOI:10.1016/j.npep.2012.02.001

PMID:22414624

Abstract

AIM

To determine whether different glycemic index (GI) diets have different effects on the acute secretion of motilin, orexin and neuropeptide Y (NPY), regulators of food intake, energy homeostasis and glucose metabolism.

METHODS

Fifty healthy volunteers were randomly assigned to two groups and were fed an isocaloric breakfast (464 kcal) containing high GI (HGI; GI=90) or low GI (LGI; GI=47) components. Serum motilin, orexin, and NPY concentrations were measured before (0 h) and 2h after the meal.

RESULTS

The concentrations of motilin, orexin-A, NPY, C-peptide, and blood glucose at 0 h were similar in both groups of subjects. However, 2 h after breakfast, the serum motilin, NPY, C-peptide, and blood glucose concentrations were increased and orexin-A concentrations were decreased in both groups. The percentage changes from 0 to 2 h [(2-h value-0-h value)/baseline×100)] in motilin (27.72±2.46% vs. 20.95±2.06%, p=0.04) and orexin-A (9.15±2.06% vs. 3.49±1.67%, p=0.038) concentrations were significantly higher in the LGI group than in the HGI group. By contrast, the percentage changes in NPY (53.7±9.73% vs. 28.1±5.2%, p=0.026) and blood glucose (12.3±3.78% vs. 1.77±2.52%, p=0.025) concentrations were significantly greater in the HGI group than in the LGI group. Although C-peptide concentrations increased significantly after breakfast in both groups, the magnitude of the increase was similar (132.69±25.15% vs. 139.98±27.29%, p=0.845). Motilin and NPY concentrations were moderately positive correlated (r=0.410, p=0.042), while orexin-A and NPY concentrations were negatively correlated (r=-0.429, p=0.033) at 2h in the LGI group.

CONCLUSIONS

A breakfast with a LGI reduced the secretion of orexin-A but significantly stimulated motilin secretion, without marked effects on the secretion of NPY. Therefore, consumption of a LGI diet may help to regulate food intake and energy expenditure in healthy individuals based on the changes in these hormones.

摘要

目的

确定不同血糖指数（GI）饮食对胃动素、食欲素和神经肽 Y（NPY）等调节食物摄入、能量平衡和葡萄糖代谢的激素的急性分泌是否有不同的影响。

方法

将 50 名健康志愿者随机分为两组，分别给予含高血糖指数（HGI；GI=90）或低血糖指数（LGI；GI=47）成分的等热量早餐（464 千卡）。在餐前（0 小时）和餐后 2 小时测量血清胃动素、食欲素和 NPY 浓度。

结果

两组受试者的胃动素、食欲素 A、NPY、C 肽和血糖浓度在 0 小时时相似。然而，早餐后 2 小时，两组血清胃动素、NPY、C 肽和血糖浓度升高，食欲素 A 浓度降低。胃动素（27.72±2.46%比 20.95±2.06%，p=0.04）和食欲素 A（9.15±2.06%比 3.49±1.67%，p=0.038）浓度从 0 小时到 2 小时的百分比变化在 LGI 组明显高于 HGI 组。相比之下，HGI 组 NPY（53.7±9.73%比 28.1±5.2%，p=0.026）和血糖（12.3±3.78%比 1.77±2.52%，p=0.025）浓度的百分比变化明显大于 LGI 组。尽管两组早餐后 C 肽浓度均显著升高，但升高幅度相似（132.69±25.15%比 139.98±27.29%，p=0.845）。LGI 组胃动素和 NPY 浓度呈中度正相关（r=0.410，p=0.042），而食欲素 A 和 NPY 浓度呈负相关（r=-0.429，p=0.033）。