Ferrand François-Régis, Gontier Eric, Guymar Sophie, Fagot Thierry, Ceccaldi Bernard, Malfuson Jean-Valère, de Revel Thierry
Service d'oncologie, HIA Val de Grâce, Paris, France.
Onkologie. 2012;35(3):118-20. doi: 10.1159/000336971. Epub 2012 Feb 20.
We report the case of a 62-year-old woman with a metastatic gastric cancer complicated by diffuse bone marrow carcinomatosis, disseminated intravascular coagulation (DIC) and microangiopathic hemolytic anemia (MHA) treated by modified FOLFOX-6 as front-line chemotherapy regimen. This chemotherapy showed clinical, morphological and biological efficiency and safety in this rare and severe hematological complication at initial diagnosis. Furthermore, this is the first case of diffuse bone carcinomatosis from a gastric cancer to be monitored by positron emission tomography integrated computed tomography (PET-CT) scan using 18-fluorodeoxyglucose (18-FDG).
我们报告了一例62岁女性转移性胃癌患者，其合并弥漫性骨髓癌转移、弥散性血管内凝血（DIC）和微血管病性溶血性贫血（MHA），采用改良FOLFOX-6作为一线化疗方案进行治疗。该化疗方案在初始诊断时针对这种罕见且严重的血液学并发症显示出临床、形态学及生物学方面的有效性和安全性。此外，这是首例使用18-氟脱氧葡萄糖（18-FDG）通过正电子发射断层扫描融合计算机断层扫描（PET-CT）对胃癌引起的弥漫性骨癌转移进行监测的病例。
