Yamauchi Masami, Okamoto Yohei, Doi Mihoko, Shinozaki Katsunori
Dept. of Clinical Oncology, Hiroshima Prefectural Hospital.
Gan To Kagaku Ryoho. 2010 Nov;37(11):2209-11.
A 66-year-old man was referred to our hospital because of a two-week history off ever and low back pain. There was a hard anal mass on rectal examination. Colonoscopy and computed tomography showed anal adenocarcinoma, multiple metastases to lymph nodes and bones. Blood test showed severe disseminated intravascular coagulation (DIC). Microscopic examination of the bone marrow aspirate revealed disseminated carcinomatosis of the bone marrow. Systemic chemotherapy (mFOLFOX6) was started, then remission of DIC and shrinkage of the tumor were observed. Although the patient had cerebral infarction during the first course of chemotherapy, he received nine courses of treatment. He died six months later because of cerebellar hemorrhage.
一名66岁男性因持续两周的发热和腰痛被转诊至我院。直肠检查发现肛门有一硬块。结肠镜检查和计算机断层扫描显示为肛门腺癌，伴有多处淋巴结和骨转移。血液检查显示严重的弥散性血管内凝血（DIC）。骨髓穿刺的显微镜检查显示骨髓弥漫性癌转移。开始进行全身化疗（mFOLFOX6），随后观察到DIC缓解和肿瘤缩小。尽管患者在第一个化疗疗程中发生了脑梗死，但他接受了九个疗程的治疗。六个月后，他因小脑出血死亡。
