Dentinger M P, Barron K D, Kohberger R C, McLean B
J Neuropathol Exp Neurol. 1979 Sep;38(5):551-64. doi: 10.1097/00005072-197909000-00008.
Quantitative electron microscopic examination was made of Betz cells of two unoperated cats as well as cats subjected to left lateral funiculotomy 5, 10, 28 and 49 days before sacrifice. The percent cytoplasmic composition of chromatolyzed, right-sided Betz cells contributed by cisternal elements of RER, Golgi apparatus and dense bodies and the percent perikaryal membrane apposed by subsurface cisterns were unchanged from the normal despite marked qualitative alterations of the cytoplasm. However, 49 days postoperatively mitochondrial numerical density of axotomized, right-sided Betz cells was significantly less than at 0, 10 and 28 days post funiculotomy. Importantly, normal-appearing Betz cells ipsilateral to corticospinal tract section showed an increase in mitochondrial numerical density 5 days postoperatively. Operation did not induce change in the % perikaryal coverage by axosomatic boutons. Retraction of axosomatic boutons, though often reported for other neuronal populations undergoing axon reaction, is not a necessary feature of the axon reaction of feline Betz cells.
对两只未手术的猫以及在处死前5、10、28和49天接受左侧脊髓外侧索切断术的猫的贝茨细胞进行了定量电子显微镜检查。尽管细胞质有明显的质性改变，但经染色质溶解的右侧贝茨细胞的细胞质组成中，由粗面内质网的池状结构、高尔基体和致密体所占的百分比，以及被表面下池状结构贴附的核周膜百分比，与正常情况相比并无变化。然而，术后49天时，切断轴突的右侧贝茨细胞的线粒体数量密度显著低于脊髓外侧索切断术后0、10和28天。重要的是，在皮质脊髓束切断术同侧外观正常的贝茨细胞在术后5天时线粒体数量密度增加。手术并未引起轴体终扣对核周覆盖百分比的变化。轴体终扣的回缩，虽然在其他经历轴突反应的神经元群体中经常有报道，但并非猫贝茨细胞轴突反应的必要特征。
