Webb D M, Van Vleet J F
Department of Veterinary Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47906.
Avian Dis. 1990 Jul-Sep;34(3):693-700.
Cystic testicular tubular dilatation was seen in ducklings fed a ration containing furazolidone at 250, 400, 550, or 700 ppm for 28 days. Gross evidence of cystic testicular dilatation was observed at necropsy in 16% (32/203) of the ducklings that survived to the end of the study. Gross testicular lesions consisted of various degrees of enlargement with increased translucency in moderately to severely enlarged testicles. Histological evidence of cystic testicular dilatation was present in 45% (41/91) of the testicles examined. Histologically, the tubules were in various states of dilatation with attenuation of the seminiferous epithelium proportional to the severity of dilatation. In the most severely affected testicles, tubules were greatly dilated, distorted, and fluid-filled, with extensively flattened epithelium visible on the inner margin of the tubule as a thin rim of cytoplasm with a protuberant nucleus. Interstitial tissues were compressed to thin septa between the dilated tubules.
给雏鸭饲喂含250、400、550或700 ppm呋喃唑酮的日粮28天后，可见睾丸囊性小管扩张。在存活至研究结束的雏鸭中，有16%（32/203）在尸检时观察到睾丸囊性扩张的大体证据。睾丸大体病变包括不同程度的肿大，中度至重度肿大的睾丸透明度增加。在检查的睾丸中，45%（41/91）有睾丸囊性扩张的组织学证据。组织学上，小管处于不同程度的扩张状态，生精上皮的变薄与扩张的严重程度成正比。在受影响最严重的睾丸中，小管极度扩张、扭曲并充满液体，在小管内缘可见广泛扁平的上皮，呈薄的细胞质边缘，细胞核突出。间质组织被压缩成扩张小管之间的薄间隔。
