Khan M Z, Zaman Q, Islam N, Muhammad G
Department of Veterinary Pathology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan.
Vet Hum Toxicol. 1995 Aug;37(4):314-8.
Broiler chicks 1 d and 3 w of age were given 0, 400, 800, or 1000 mg furazolidone (Fz)/kg feed for 4 w. Bi-ventricular heart dilatation (as measured by increases in ventricular diameter and thinning of the ventricular walls) was present in 1-d-old chicks fed 800 mg Fz, whereas in 3-w-old groups these changes occurred at 1000 mg Fz. There was no heart hypertrophy. Microscopic changes in the heart were not discernible in and Fz-fed birds. The liver had congestion and cytoplasmic vacuolation of hepatocytes. About 37-50% of the male birds in the different Fz-fed groups had testicular degeneration varying from mild to cystic enlargement. The degenerated testes had dilatation of seminiferous tubules; in cystic testes the seminiferous tubules were extremely dilated and had flattened epithelium. The interstitial tissue between the dilated tubules was compressed and atrophic.
给1日龄和3周龄的肉鸡雏鸡分别饲喂含0、400、800或1000 mg呋喃唑酮（Fz）/kg饲料的日粮，持续4周。饲喂800 mg Fz的1日龄雏鸡出现双心室扩张（通过心室直径增加和心室壁变薄来衡量），而在3周龄组中，这些变化出现在饲喂1000 mg Fz的雏鸡中。未出现心脏肥大。在饲喂Fz的雏鸡中，心脏的微观变化不明显。肝脏出现充血和肝细胞胞质空泡化。在不同Fz饲喂组中，约37%-50%的雄鸡出现从轻度到囊性肿大不等的睾丸退化。退化的睾丸生精小管扩张；在囊性睾丸中，生精小管极度扩张，上皮细胞扁平。扩张小管之间的间质组织受压且萎缩。
