使用铂纳米线作为催化剂高效合成 N-取代的异吲哚啉酮和酞嗪酮。

Highly efficient synthesis of N-substituted isoindolinones and phthalazinones using Pt nanowires as catalysts.

机构信息

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.

出版信息

Org Lett. 2012 Apr 6;14(7):1876-9. doi: 10.1021/ol300471a. Epub 2012 Mar 15.

DOI:10.1021/ol300471a

PMID:22420427

Abstract

A series of N-substituted isoindolinones have been successfully synthesized through the reductive C-N coupling and intramolecular amidation of 2-carboxybenzaldehyde and amines. This one-pot synthesis gives excellent yields using ultrathin Pt nanowires as catalysts under 1 bar of hydrogen. These unsupported catalysts can also be used for the synthesis of phthalazinones in high yield when hydrazine or phenyl hydrazine is used instead of amines.

摘要

通过 2-羧基苯甲醛和胺的还原 C-N 偶联和分子内酰胺化，成功合成了一系列 N-取代的异吲哚啉酮。在 1 巴氢气的压力下，使用超薄 Pt 纳米线作为催化剂，一锅法合成得到了极好的产率。当使用肼或苯肼代替胺时，这些无载体催化剂也可用于高产率合成酞嗪酮。