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咽鼓管反流在分泌性中耳炎发病机制中的作用。

Role of nasopharyngeal reflux in the etiology of otitis media with effusion.

机构信息

Department of Otorhinolaryngology, Ankara Training and Research Hospital, Ankara, Turkey.

出版信息

J Otolaryngol Head Neck Surg. 2011 Dec;40(6):499-503.

Abstract

OBJECTIVES

To investigate nasopharyngeal reflux in children with otitis media with effusion (OME) using 24-hour dual-probe pH monitoring and to determine whether nasopharyngeal reflux has a role in the etiology of OME.

METHODS

The study was performed in 20 children with OME and adenoid hypertrophy (± tonsillar hypertrophy) and in 20 controls who had adenoid hypertrophy (± tonsillar hypertrophy) without any ear problems. All subjects underwent 24-hour pH monitoring with a dual probe. The proximal probe was placed in the nasopharynx in this procedure.

RESULTS

In the study group, 25% (5 of 20) of the patients were found to have nasopharyngeal reflux and 30% (6 of 20) of them were found to have esophageal reflux. On the other hand, nasopharyngeal reflux was detected in 3 (15%) of 20 children in the control group, whereas esophageal reflux was detected in 3 (15%) of them. When the groups were compared for the incidence of nasopharyngeal reflux and esophageal reflux, the difference was not found to be statistically significant (p > .05).

CONCLUSIONS

We detected higher nasopharyngeal and esophageal reflux rates in the OME group, although the difference between the groups studied was not statistically significant. This issue must be addressed in new studies performed in larger series.

摘要

目的

通过 24 小时双探头 pH 监测来研究分泌性中耳炎(OME)患儿的鼻咽反流情况,并确定鼻咽反流是否与 OME 的病因有关。

方法

本研究纳入了 20 例伴有腺样体肥大(±扁桃体肥大)的 OME 患儿和 20 例单纯腺样体肥大(±扁桃体肥大)但无耳部问题的对照组患儿。所有受试者均接受了 24 小时 pH 双探头监测。该过程中,近端探头被放置在鼻咽部。

结果

在研究组中,有 25%(5 例)的患者被发现存在鼻咽反流,30%(6 例)的患者存在食管反流。另一方面,对照组中有 3 例(15%)患儿存在鼻咽反流,3 例(15%)患儿存在食管反流。对两组的鼻咽反流和食管反流发生率进行比较,差异无统计学意义(p>0.05)。

结论

尽管研究组间的差异无统计学意义,但我们在 OME 组中检测到了更高的鼻咽和食管反流率。这一问题必须在更大系列的新研究中得到解决。

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