Department of Neurology, Mayo Clinic, Rochester, Minnesota 55901, USA.
Semin Neurol. 2012 Feb;32(1):85-94. doi: 10.1055/s-0032-1306391. Epub 2012 Mar 15.
The understanding of the genetic basis of late-onset leukoencephalopathies has continued to increase in recent years. The most commonly presenting leukoencephalopathies in adulthood can be late-onset manifestations of metabolic pathways. The understanding of these diagnoses is crucial to the evaluation of adult patients presenting with leukoencephalopathies. The authors provide an overview of the common leukoencephalopathies in adulthood, the current understanding of the pathology, and genetics of these disorders with typical imaging findings. When available, treatment options will be discussed.
近年来，人们对迟发性脑白质病的遗传基础的认识不断加深。在成年期最常见的脑白质病可能是代谢途径的迟发性表现。了解这些诊断对评估成年期出现脑白质病的患者至关重要。作者概述了成人常见的脑白质病，以及这些疾病的病理和遗传学，以及典型的影像学表现。如有可能，将讨论治疗选择。
