Utrecht Stroke Centre, Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands.
J Neurol Neurosurg Psychiatry. 2012 May;83(5):541-2. doi: 10.1136/jnnp-2011-301147. Epub 2012 Mar 15.
Smoking and hypertension increase the risk of aneurismal subarachnoid haemorrhage (SAH) two to threefold whereas a familial predisposition increases the risk sixfold. We assessed the additional risk of smoking and hypertension for the presence of an intracranial aneurysm (IA) in first-degree relatives of patients with familial SAH.
We studied first-degree relatives of patients with familial SAH who were screened for the presence of aneurysms. RRs with corresponding 95% CIs for the risk of IA were calculated for smoking and hypertension.
The RRs were 1.5 (95% CI 0.7 to 3.2) for smoking, 1.9 (95% CI 1.0 to 3.7) for hypertension and 2.7 (95% CI 1.4 to 5.3) for smoking plus hypertension. The increased RR for hypertension was found in both women and men, but the increased RR for smoking was found in women only.
The extent of the increased risk of smoking and hypertension for the presence of IA in first-degree relatives of patients with familial SAH is similar to that in patients without familial predisposition. Risk factor profiles should be included in future genetic studies.
吸烟和高血压使蛛网膜下腔出血（SAH）的风险增加两到三倍，而家族易感性使风险增加六倍。我们评估了吸烟和高血压对家族性 SAH 患者一级亲属颅内动脉瘤（IA）存在的额外风险。
我们研究了家族性 SAH 患者一级亲属的筛查结果，以评估 IA 的存在。计算了吸烟和高血压的 IA 风险的 RR 和相应的 95%CI。
吸烟的 RR 为 1.5（95%CI 0.7 至 3.2），高血压的 RR 为 1.9（95%CI 1.0 至 3.7），吸烟加高血压的 RR 为 2.7（95%CI 1.4 至 5.3）。高血压的 RR 增加在女性和男性中均可见，但吸烟的 RR 增加仅见于女性。
家族性 SAH 患者一级亲属 IA 存在的吸烟和高血压风险增加的程度与无家族易感性的患者相似。危险因素谱应纳入未来的遗传研究中。
