生，还是死：志贺氏菌自有答案。

To die or not to die: Shigella has an answer.

机构信息

Biocenter, Department of Microbiology, University of Würzburg, Würzburg, Germany.

出版信息

Cell Host Microbe. 2012 Mar 15;11(3):219-21. doi: 10.1016/j.chom.2012.02.004.

DOI:10.1016/j.chom.2012.02.004

Abstract

Invasion of epithelial cells by Shigella is a critical step in the pathogenesis of bacillary dysentery. In this issue of Cell Host & Microbe, Bergounioux et al. (2012) uncover a complex interplay of proinvasion, prosurvival, and prodeath signals centered on the activation of calpain protease by the Shigella VirA protein.

摘要

志贺氏菌侵入上皮细胞是细菌性痢疾发病机制中的关键步骤。在本期《细胞宿主与微生物》中，Bergounioux 等人（2012）揭示了以 Shigella VirA 蛋白激活钙蛋白酶蛋白酶为中心的促入侵、促存活和促死亡信号的复杂相互作用。