Laboratory of Reproductive Biology, Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark.
Fertil Steril. 2012 Jun;97(6):1394-8.e1. doi: 10.1016/j.fertnstert.2012.02.036. Epub 2012 Mar 15.
To investigate ovarian reserve and ovarian function in women transplanted with frozen/thawed ovarian tissue.
Retrospective cohort study.
University hospital.
PATIENT(S): 18 women transplanted with their own frozen/thawed ovarian tissue.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Levels of antimüllerian hormone (AMH), duration of function of the transplanted ovarian tissue, outcome of assisted reproduction.
RESULT(S): Of the 18 women who received transplanted ovarian tissue, levels of AMH were measured in 12 women; AMH never exceed a concentration of 1 ng/mL, and in several cases they were below the detection limit of the assay in combination with regular menstrual cycles. Two women with AMH below the detection limit conceived spontaneously. The duration of function of the transplants was between 9 months and 7 years and still functioning. Twelve women received assisted reproduction therapy; in 72 cycles, 65 oocytes were retrieved. The pregnancy rate and live-birth rate per cycle were 6.9% (5 of 72) and 2.8% (2 of 72), respectively.
CONCLUSION(S): The relatively poor outcome of assisted reproduction in women transplanted with frozen/thawed ovarian tissue may reflect reduced follicular selection rather than defective or aged oocytes. In normal women, reduced follicular selection with age may be part of explaining the decline in female fecundity with increasing age.
研究冷冻/解冻卵巢组织移植后女性的卵巢储备和卵巢功能。
回顾性队列研究。
大学医院。
18 名接受自身冷冻/解冻卵巢组织移植的女性。
无。
抗苗勒管激素（AMH）水平、移植卵巢组织功能持续时间、辅助生殖结局。
在接受卵巢组织移植的 18 名女性中，有 12 名女性测量了 AMH 水平；AMH 从未超过 1ng/ml，并且在一些情况下，结合规律的月经周期，AMH 水平低于检测限。两名 AMH 低于检测限的女性自然受孕。移植的功能持续时间为 9 个月至 7 年，仍在发挥作用。12 名女性接受了辅助生殖治疗；在 72 个周期中，共取出 65 个卵母细胞。每个周期的妊娠率和活产率分别为 6.9%（72 个周期中的 5 个）和 2.8%（72 个周期中的 2 个）。
冷冻/解冻卵巢组织移植后女性辅助生殖的相对较差结局可能反映了卵泡选择减少，而不是卵母细胞有缺陷或老化。在正常女性中，随着年龄的增长，卵泡选择减少可能是解释女性生育能力随年龄增长而下降的部分原因。
