Department of Biosciences, Biotechnologies and Pharmacological Sciences, Italy.
Clin Biochem. 2012 Jun;45(9):631-6. doi: 10.1016/j.clinbiochem.2012.02.025. Epub 2012 Mar 9.
To investigate peripheral brain-derived neurotrophic factor (BDNF) concentrations in the perioperative period, their relationship with transforming growth factor-β1 (TGF-β1 tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-6 genetics.
Prospective, observational study. BDNF, TGF-β1, IL-6 and TNF-α were analysed at baseline (T0), 5 h (T1), 24 h (T2) and 5 days (T3) after surgery, in 21 patients. The IL-6 -174 G/C polymorphism was genotyped.
Serum BDNF concentrations decreased (P=0.048), correlated with TGF-β1 (r=0.610 at T1, r=0.493 at T2, r=0.554 at T3). Plasma BDNF concentrations raised (P=0.049), correlated with IL-6 and TNF-α at T1 (r=0.495 and r=0.441, respectively). BDNF response was predictable from TNF-α and IL-6 concentrations and the IL-6 -174 G/C genotype.
Serum and plasma BDNF concentrations could relate to platelet activation and inflammatory response, respectively. IL-6 genetics played a role in the BDNF acute response.
研究围手术期外周脑源性神经营养因子（BDNF）浓度及其与转化生长因子-β1（TGF-β1）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和 IL-6 遗传学的关系。
前瞻性观察性研究。在 21 例患者中，于基线（T0）、术后 5 小时（T1）、24 小时（T2）和 5 天（T3）时分析 BDNF、TGF-β1、IL-6 和 TNF-α。对 IL-6-174 G/C 多态性进行基因分型。
血清 BDNF 浓度降低（P=0.048），与 TGF-β1 相关（T1 时 r=0.610，T2 时 r=0.493，T3 时 r=0.554）。血浆 BDNF 浓度升高（P=0.049），与 T1 时的 IL-6 和 TNF-α相关（r=0.495 和 r=0.441）。BDNF 的反应可以从 TNF-α和 IL-6 浓度和 IL-6-174 G/C 基因型来预测。
血清和血浆 BDNF 浓度可能分别与血小板激活和炎症反应有关。IL-6 遗传学在 BDNF 的急性反应中起作用。
