Śnit Mirosław, Nabrdalik Katarzyna, Gawlik Radosław, Wystrychowski Grzegorz, Łącka-Gaździk Beata, Kuźniewicz Roman, Gumprecht Janusz, Wielkoszyński Tomasz, Łabuz-Roszak Beata, Grzeszczak Władysław
Department of Internal Medicine, Diabetology and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland.
Department of Internal Medicine, Allergology and Clinical Immunology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
Postepy Dermatol Alergol. 2020 Dec;37(6):932-937. doi: 10.5114/ada.2019.87707. Epub 2019 Sep 4.
Even though uremic pruritus (UP) is very troublesome for haemodialysis (HD) patients, its underlying mechanism is not fully understood.
Due to the possible role of brain-derived neurotrophic factor (BDNF) and its higher serum concentration in haemodialysis diabetic patients compared to non-diabetic ones, this study is aimed to evaluate its association with UP among diabetic and non-diabetic patients on maintenance HD.
A total of 94 patients were enrolled into the study. A visual analogue scale (VAS) was used to assess pruritus.
No differences were found between the observed study groups in terms of BDNF serum concentration, other biochemical markers, sleep disturbances, or pruritus presentation.
BDNF serum concentration was not found to be associated with UP among HD patients, however further studies are worth performing on a larger group of individuals.
尽管尿毒症瘙痒(UP)对血液透析(HD)患者来说非常困扰,但其潜在机制尚未完全明确。
鉴于脑源性神经营养因子(BDNF)可能发挥的作用,以及与非糖尿病血液透析患者相比,糖尿病血液透析患者血清中BDNF浓度更高,本研究旨在评估维持性血液透析的糖尿病和非糖尿病患者中BDNF与UP的相关性。
共94例患者纳入本研究。采用视觉模拟评分法(VAS)评估瘙痒情况。
在观察的研究组之间,BDNF血清浓度、其他生化指标、睡眠障碍或瘙痒表现方面均未发现差异。
在血液透析患者中,未发现BDNF血清浓度与UP相关,然而值得对更大规模的人群进行进一步研究。