Neurology Department, Hospital Privado de Comunidad, Mar del Plata, Argentina.
Acta Neurol Belg. 2012 Mar;112(1):81-4. doi: 10.1007/s13760-012-0022-4. Epub 2012 Feb 3.
Topiramate is a sulfamate-substituted monosaccharide mainly used to treat epilepsy in children and adults and prophylaxis of migraine. This article describes a case of topiramate-induced acute transient myopia. The underlying mechanism and management is discussed. A 13-year-old female complained of sudden onset of blurred vision; 7 days prior to this she had commenced topiramate therapy for migraine prophylaxis. Visual acuity was reduced in both eyes. Examination revealed myopic refractive changes which resolved quickly following discontinuation of the drug. An MRI showed uveoscleral and subcutaneous cellular tissue abnormalities in the T1 contrasted images.
托吡酯是一种磺酰胺取代的单糖，主要用于治疗儿童和成人的癫痫发作和偏头痛的预防。本文描述了一例托吡酯引起的急性短暂性近视。讨论了其潜在机制和治疗方法。一名 13 岁女性患者主诉突发性视力模糊；在此之前 7 天，她开始服用托吡酯预防偏头痛。双眼视力均下降。检查发现近视性屈光变化，停药后迅速恢复。MRI 显示 T1 对比图像中有葡萄膜巩膜和皮下细胞组织异常。
