托吡酯诱发急性短暂性近视：一例报告。
Topiramate induced acute transient myopia: a case report.
作者信息
Gawley Sandra D
机构信息
St Paul's Eye Unit, The Royal Liverpool University Hospital Prescot Street, Liverpool, Merseyside UK.
出版信息
Cases J. 2009 Jul 3;2:7430. doi: 10.4076/1757-1626-2-7430.
INTRODUCTION
Topiramate is a sulfamate-substituted monosaccharide mainly used to treat epilepsy in children and adults and for prophylaxis of migraine. This article describes a case of topiramate induced acute transient myopia. The underlying mechanism and management is discussed.
CASE PRESENTATION
A 34-year-old female complained of sudden onset of blurred vision, 9 days prior to this she had commenced topiramate therapy for migraine prophylaxis. Visual acuity was reduced to 6/36 right eye and 2/60 left eye. Examination revealed ocular anatomical and myopic refractive changes which resolved quickly following discontinuation of the drug.
CONCLUSION
Ophthalmologists need to be aware of the potential ocular side effects of topiramate. Although relatively rare prompt recognition is key so appropriate management can be instituted.
引言
托吡酯是一种氨基磺酸酯取代的单糖，主要用于治疗儿童和成人癫痫以及预防偏头痛。本文描述了一例托吡酯诱发急性短暂性近视的病例。并对其潜在机制及处理方法进行了讨论。
病例介绍
一名34岁女性主诉视力突然模糊，在此之前9天她开始服用托吡酯预防偏头痛。右眼视力降至6/36，左眼视力降至2/60。检查发现眼部解剖结构和近视屈光改变，停药后很快恢复。
结论
眼科医生需要意识到托吡酯潜在的眼部副作用。虽然相对罕见，但及时识别是关键，以便能够采取适当的处理措施。
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