Nadaoka Isao, Watanabe Kazuki, Yasue Masaaki, Sami Manabu, Kitagawa Yasushi, Mimaki Yoshihiro
Research Laboratories for Fundamental Technology of Food, Asahi Group Holdings, Ltd., Moriya 302-0106, Japan.
Nat Prod Commun. 2012 Jan;7(1):15-8.
Dried rhizomes of Cimicifuga racemosa (CR), known as black cohosh, have been widely used as a herbal dietary supplement in the treatment of menopausal symptoms. Here we used experimental mouse stress models to investigate the role of anti-stress food factors, and found that a CR extract had stress-relieving effects. A single oral administration of CR extract (1,000 mg/kg) significantly attenuated plasma corticosterone and aspartate aminotransferase (AST) levels that had increased as a result of enforced immobilization. Bioassay-guided fractionation of the CR extract resulted in the isolation of 10 triterpenes, among which actein, 23-epi-26-deoxyactein, and cimiracemoside F (100 mg/kg, per os) were shown to contribute to the anti-stress effects. Furthermore, the CR extract significantly prevented the development of water immersion stress-induced gastric mucosal ulcers in rats. We propose that the CR extract might be suitable for the prevention and treatment of stress-related disorders.
总状升麻（CR）的干燥根茎，即黑升麻，已被广泛用作治疗更年期症状的草药膳食补充剂。在此，我们使用实验性小鼠应激模型来研究抗应激食物因子的作用，发现CR提取物具有缓解应激的作用。单次口服CR提取物（1000毫克/千克）可显著降低因强制固定而升高的血浆皮质酮和天冬氨酸转氨酶（AST）水平。对CR提取物进行生物测定指导的分级分离，得到了10种三萜类化合物，其中23-表-26-脱氧升麻素、升麻素和升麻糖苷F（100毫克/千克，口服）显示出对应激的缓解作用。此外，CR提取物显著预防了大鼠水浸应激诱导的胃黏膜溃疡的发生。我们认为CR提取物可能适用于预防和治疗与应激相关的疾病。
