Maekawa A, Matsushima Y, Onodera H, Shibutani M, Ogasawara H, Kodama Y, Kurokawa Y, Hayashi Y
Division of Pathology, National Institute of Hygienic Sciences, Tokyo, Japan.
Food Chem Toxicol. 1990 Aug;28(8):581-6. doi: 10.1016/0278-6915(90)90159-k.
The long-term toxicity/carcinogenicity of musk xylol, a synthetic nitro musk, was examined in B6C3F1 mice of both sexes. Musk xylol was administered at dietary levels of 0 (control), 0.075 or 0.15% for 80 wk. The overall tumour incidences in all treated groups of both sexes were significantly higher than those in the corresponding controls. Combined malignant and benign liver cell tumours were clearly increased in both sexes, and in males a positive significant trend was also noted for the occurrence of hepatocellular carcinomas. In males the incidence of Harderian gland tumours was also significantly greater in treated groups than in controls. Some other neoplasms, such as lung tumours in both sexes and Harderian gland tumours and lymphomas in females, occurred in greater numbers in the treated groups, although the differences were not statistically significant in comparison with the controls. In addition, the incidences and total numbers of malignant tumours were significantly increased in treated groups of both sexes, although the increases were not dose dependent. The results demonstrated that musk xylol is carcinogenic in B6C3F1 mice when given at dose levels of 0.075 or 0.15% in the diet for 80 wk.
研究了合成硝基麝香二甲苯麝香的长期毒性/致癌性，受试动物为B6C3F1雌雄小鼠。二甲苯麝香在饲料中的添加水平分别为0（对照）、0.075%或0.15%，持续给药80周。所有处理组雌雄小鼠的总体肿瘤发生率均显著高于相应对照组。雌雄两性的肝恶性和良性细胞瘤均明显增加，雄性肝细胞癌的发生也呈现出显著的阳性趋势。雄性处理组的Harderian腺肿瘤发生率也显著高于对照组。其他一些肿瘤，如雌雄两性的肺肿瘤以及雌性的Harderian腺肿瘤和淋巴瘤，在处理组中的发生数量较多，尽管与对照组相比差异无统计学意义。此外，雌雄两性处理组的恶性肿瘤发生率和总数均显著增加，尽管增加并不依赖剂量。结果表明，当二甲苯麝香在饲料中的剂量水平为0.075%或0.15%，持续给药80周时，对B6C3F1小鼠具有致癌性。
