Yoshiki Ryutaro, Nakamura Motonobu, Tokura Yoshiki
Department of Dermatology University of Occupational and Environmental Health, Japan.
J UOEH. 2012 Mar 1;34(1):77-83. doi: 10.7888/juoeh.34.77.
Skin is a large organ which protects our inner body from external stresses. Skin serves not only as a physical barrier but also as an important immune system. Ultraviolet rays B (UVB) activate melanin synthesis by melanocytes in the skin. Melanin, in turn, absorbs UVB and protects the skin from overexposure to UVB. In addition, it is generally known that UVB suppresses immune reaction in the skin. This phenomenon is applied to the treatment of cutaneous diseases such as psoriasis and vitiligo. UVB-induced immunosuppression is mediated by regulatory T cells (Tregs). We and other groups have figured out the mechanism of UVB-induced antigen specific immunosuppression. Here we propose that the role of UVB-mediated immunosuppression is the inhibition of self-destruction against external stresses.
皮肤是一个大型器官，可保护我们的身体内部免受外部压力。皮肤不仅作为物理屏障，还作为重要的免疫系统。紫外线B（UVB）可激活皮肤中黑素细胞的黑色素合成。反过来，黑色素吸收UVB，保护皮肤免受UVB过度照射。此外，众所周知，UVB会抑制皮肤中的免疫反应。这种现象被应用于治疗银屑病和白癜风等皮肤病。UVB诱导的免疫抑制由调节性T细胞（Tregs）介导。我们和其他团队已经弄清楚了UVB诱导的抗原特异性免疫抑制机制。在此我们提出，UVB介导的免疫抑制作用是抑制针对外部压力的自我破坏。
