Department of Radiology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK.
Pediatr Radiol. 2012 Jun;42(6):699-705. doi: 10.1007/s00247-011-2339-1. Epub 2012 Mar 20.
Melanotic neuroectodermal tumour of infancy (MNTI) is a rare neoplasm of neural crest origin.
To describe three further cases of MNTI, with emphasis on CT and MRI findings.
Data for children with histologically confirmed MNTI following biopsy or surgery were retrieved. Three children with available imaging at the time of diagnosis were included in the study.
All three children had primary tumour in the head and neck region: one in the maxilla, one in the occipital bone (extra-axial but with intracranial extension) and one with an unusual tumour growing exophytically from the subcutaneous tissues adjacent to the occipital bone. All tumours were iso/hypointense both on T1- and T2-weighted MRI, and showed marked contrast enhancement in their non-ossified components. CT allowed identification of bone destruction and remodelling.
Our findings are consistent with previously reported cases of MNTI regarding age at presentation and location in the head and neck region. Our MR findings did not demonstrate the typical pattern of T1-shortening expected from melanin deposition.
婴儿黑色素神经外胚层肿瘤（MNTI）是一种起源于神经嵴的罕见肿瘤。
描述另外三例 MNTI 病例，重点介绍 CT 和 MRI 表现。
检索经活检或手术证实为 MNTI 的患儿的临床资料。对当时有影像学资料的 3 例患儿进行研究。
3 例患儿的原发肿瘤均位于头颈部：1 例位于上颌骨，1 例位于枕骨（硬膜外，但有颅内延伸），1 例肿瘤呈外生性生长，从枕骨附近的皮下组织突出。所有肿瘤在 T1 加权和 T2 加权 MRI 上均呈等/低信号，非骨化成分明显强化。CT 可识别骨破坏和重塑。
我们的发现与之前报道的头颈部 MNTI 病例在发病年龄和位置上一致。我们的 MRI 结果并未显示出预期的黑色素沉积导致的 T1 缩短的典型模式。
