Koschmieder Steffen, Schemionek Mirle
Medizinische Klinik A, Universitätsklinikum Münster Münster, Germany.
Am J Blood Res. 2011;1(1):65-75. Epub 2011 Jun 7.
Mouse models of human malignancy have greatly enhanced our understanding of disease pathophysiology and have led to novel therapeutic approaches, some with extraordinary success, one such example being inhibition of the BCR-ABL1 oncogene in chronic myeloid leukaemia (CML). Here, we review aspects of the biology of CML that have been uncovered at least in part through the generation and analysis of retroviral and transgenic mouse models of BCR-ABL1 disease. It can be expected that these models will also serve as important tools in the future, especially in the rational design of strategies to eradicate leukemic stem cells and potentially cure CML as well as other cancers.
人类恶性肿瘤的小鼠模型极大地增进了我们对疾病病理生理学的理解，并催生了新的治疗方法，其中一些取得了非凡的成功，慢性髓性白血病（CML）中对BCR-ABL1致癌基因的抑制就是一个例子。在此，我们综述了CML生物学的一些方面，这些方面至少部分是通过生成和分析BCR-ABL1疾病的逆转录病毒和转基因小鼠模型而发现的。可以预期，这些模型在未来也将成为重要工具，特别是在合理设计根除白血病干细胞并有可能治愈CML及其他癌症的策略方面。
