Sosenko J M, Kato M, Soto R, Goldberg R B
Department of Medicine, University of Miami School of Medicine, FL 33101.
J Clin Epidemiol. 1990;43(11):1149-56. doi: 10.1016/0895-4356(90)90016-i.
Relations between lipoprotein indices and the waist/hip ratio (WHR) were examined in normoglycemic subjects (124 women and 63 men). Among women, an atherogenic lipoprotein pattern was strongly associated with WHR. The relation was greater than that of the lipoprotein pattern with either the body mass index or the subscapular/triceps ratio, and was independent of these adiposity measures. The association between low-density-lipoprotein cholesterol (LDL-cholesterol) and WHR was much stronger in thinner women than in those more obese (r = 0.64 vs r = 0.22, p = 0.001 for difference). Men had a more atherogenic lipoprotein pattern than women; however, with allowances for WHR the lipoprotein patterns were similar. These findings suggest that: (1) WHR is more strongly related to plasma lipoproteins than other adiposity measures; (2) there is effect modification by the extent of adiposity for the relation between LDL-cholesterol and WHR; and (3) the adipose distribution may be important in explaining lipoprotein differences between men and women.
在血糖正常的受试者（124名女性和63名男性）中，研究了脂蛋白指标与腰臀比（WHR）之间的关系。在女性中，致动脉粥样硬化脂蛋白模式与腰臀比密切相关。这种关系比脂蛋白模式与体重指数或肩胛下/三头肌比值的关系更强，且独立于这些肥胖指标。低密度脂蛋白胆固醇（LDL-胆固醇）与腰臀比之间的关联在较瘦女性中比在肥胖女性中更强（r = 0.64对r = 0.22，差异p = 0.001）。男性的脂蛋白模式比女性更具致动脉粥样硬化性；然而，考虑到腰臀比后，脂蛋白模式相似。这些发现表明：（1）腰臀比与血浆脂蛋白的关系比其他肥胖指标更强；（2）LDL-胆固醇与腰臀比之间的关系存在肥胖程度的效应修饰；（3）脂肪分布可能在解释男女脂蛋白差异方面很重要。
