Terry R B, Wood P D, Haskell W L, Stefanick M L, Krauss R M
Stanford Center for Research in Disease Prevention, Stanford University School of Medicine, California 94305.
J Clin Endocrinol Metab. 1989 Jan;68(1):191-9. doi: 10.1210/jcem-68-1-191.
Anatomical adipose tissue distribution patterns are reported to relate to plasma lipids and risk of cardiovascular disease. Waist to hip girth ratios (WHR) and subscapular 10 triceps skinfold thickness ratios (STR) were compared with percent body fat and body mass index values as correlates of plasma lipids and lipoprotein cholesterol and serum lipoprotein subfraction mass by analytic ultracentrifugation in 81 sedentary middle-aged men in a typical range of adiposity. WHR was significantly and positively correlated with plasma concentrations of triglycerides, cholesterol, and low and very low density lipoprotein (LDL and VLDL) cholesterol and inversely correlated with high density lipoprotein (HDL) cholesterol. STR followed these trends, though less strongly, in relation to plasma triglycerides, VLDL cholesterol, and HDL cholesterol. Pronounced differences were found between regional adiposity patterns in their relationships to lipoprotein subfractions, as determined by analytic ultracentrifugation. WHR was negatively correlated with HDL2 (flotation rate F(1.2) 3.5-9), positively with small LDL (S.f 0-7), intermediate density lipoprotein (S.f 12-20), and VLDL (S.f 20-400), while STR correlated with larger LDL (S.f 7-12) and larger VLDL (S.f 60-400). Overall adiposity was not significantly associated with plasma lipoprotein levels after adjusting for regional adiposity patterns. Plasma sex hormone-binding globulin and percent free testosterone were associated with regional adiposity, but did not account for the correlations between WHR and lipoproteins. WHR and STR are measures of fat distribution that correlate with plasma lipoprotein profiles consistent with cardiovascular disease risk and have different relationships to lipoprotein mass subfractions.
据报道，解剖学上的脂肪组织分布模式与血浆脂质及心血管疾病风险相关。在81名处于典型肥胖范围内的久坐中年男性中，将腰臀围比（WHR）和肩胛下/肱三头肌皮褶厚度比（STR）与体脂百分比和体重指数值进行比较，作为血浆脂质、脂蛋白胆固醇以及通过分析超速离心法测定的血清脂蛋白亚组分质量的相关指标。WHR与甘油三酯、胆固醇、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）胆固醇的血浆浓度呈显著正相关，与高密度脂蛋白（HDL）胆固醇呈负相关。STR在与血浆甘油三酯、VLDL胆固醇和HDL胆固醇的关系上也呈现出这些趋势，不过相关性较弱。通过分析超速离心法确定，区域肥胖模式在与脂蛋白亚组分的关系上存在明显差异。WHR与HDL2（漂浮率F(1.2) 3.5 - 9）呈负相关，与小LDL（沉降系数S.f 0 - 7）、中密度脂蛋白（S.f 12 - 20）和VLDL（S.f 20 - 400）呈正相关，而STR与较大的LDL（S.f 7 - 12）和较大的VLDL（S.f 60 - 400）相关。在调整区域肥胖模式后，总体肥胖与血浆脂蛋白水平无显著关联。血浆性激素结合球蛋白和游离睾酮百分比与区域肥胖相关，但不能解释WHR与脂蛋白之间的相关性。WHR和STR是脂肪分布的测量指标，与符合心血管疾病风险的血浆脂蛋白谱相关，并且与脂蛋白质量亚组分具有不同的关系。
