Ayçiçek Abdullah, Kahveci Orhan Kemal, Miman Murat Cem, Duran Abidin, Yildiz Hüseyin
Department of Otolaryngology, Afyon Kocatepe University, Afyonkarahisar, Turkey.
ORL J Otorhinolaryngol Relat Spec. 2012;74(2):110-5. doi: 10.1159/000336738. Epub 2012 Mar 16.
The aim of the present study was to evaluate the outcomes of combined oral steroid, nasal steroid and surgical therapy in patients with impaired olfaction due to nasal polyposis.
This prospective observational study was undertaken in the otolaryngology department of a university hospital. During the study, 19 nasal polyposis patients were evaluated three times, i.e. before oral steroid therapy, before surgery (after steroid therapy) and after surgery, with smell identification tests, acoustic rhinometry, subjective smell score, endoscopic grading and a visual analog scale for nasal obstruction.
All subjective and objective measures were significantly improved after medical and surgical therapy (p < 0.01). The median smell identification score improved from 2 (interquartile range 0-4) to 5 (interquartile range 4-7) after combined therapy. Smell identification scores were found to be modestly correlated with all other examination findings.
Combined therapy seems efficient in improving smell identification scores of nasal polyposis patients.
本研究旨在评估口服类固醇、鼻用类固醇及手术联合治疗对鼻息肉所致嗅觉障碍患者的疗效。
本前瞻性观察性研究在一所大学医院的耳鼻喉科进行。研究期间，对19例鼻息肉患者进行了三次评估，即口服类固醇治疗前、手术前（类固醇治疗后）及手术后，采用嗅觉识别测试、鼻声反射、主观嗅觉评分、内镜分级及鼻塞视觉模拟量表进行评估。
药物及手术治疗后，所有主观及客观指标均有显著改善（p < 0.01）。联合治疗后，嗅觉识别评分中位数从2（四分位间距0 - 4）提高至5（四分位间距4 - 7）。嗅觉识别评分与所有其他检查结果呈中度相关。
联合治疗似乎能有效提高鼻息肉患者的嗅觉识别评分。
