Vdovenko A M
Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(12):9-15.
The structure of the first psychotic episode of juvenile endogenous intermittent psychosis with the dominance of depressive and delusional disorders was studied in a sample of 50 male patients aged 16-25 years. Three types of first episodes were singled out: episodes with homonomous structure - 11 (22%) patients, heteronomous episodes with the dominance of delusional disorders - 20 (40%) patients and heteronomous episodes with the dominance of depressive disorders - 19 (38%) patients. The differences between these types were determined by characteristics of the structure, the ratio of affective to delusional symptomatology, dynamic changes in the status, objective measures of the PANSS and CDSS. The main characteristics of these states due to the pathoplastic effect of the age factor were revealed. The authors suggest that the typological subdivision is significant for the diagnosis and prognosis of an endogenous psychosis with manifest depressive-delusional episodes. This suggestion should be verified in the follow-up study.
在50名年龄在16至25岁的男性患者样本中，研究了以抑郁和妄想障碍为主导的青少年内源性间歇性精神病首次发作的结构。区分出三种首次发作类型：具有自主性结构的发作——11名（22%）患者，以妄想障碍为主导的他主性发作——20名（40%）患者，以及以抑郁障碍为主导的他主性发作——19名（38%）患者。这些类型之间的差异由结构特征、情感症状与妄想症状之比、病情动态变化、阳性和阴性症状量表（PANSS）及临床痴呆评定量表（CDSS）的客观测量结果决定。揭示了由于年龄因素的病理塑形作用导致的这些状态的主要特征。作者认为，这种类型学细分对于伴有明显抑郁 - 妄想发作的内源性精神病的诊断和预后具有重要意义。这一建议应在后续研究中得到验证。
