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慢性损伤外周神经中的电场传递。

Ephaptic transmission in chronically damaged peripheral nerves.

作者信息

Seltzer Z, Devor M

出版信息

Neurology. 1979 Jul;29(7):1061-4. doi: 10.1212/wnl.29.7.1061.

DOI:10.1212/wnl.29.7.1061
PMID:224343
Abstract

Several weeks after damage of the sciatic nerve in adult rats, a stable electrical (ephaptic) interaction forms between pairs of injured sensory and motor axons. Fiber-fiber interaction occurs when the nerve ends in a neuroma, after end-to-end nerve suture and after nerve crush injury. Unlike the transient "artificial synapse" created acutely on section of a nerve, this form of crosstalk is long-lasting. Its existence lends support to the hypothesis that ephaptic interaction is an important factor in neurologic pathophysiology.

摘要

成年大鼠坐骨神经损伤几周后,受损的感觉和运动轴突对之间会形成稳定的电(ephaptic)相互作用。当神经在神经瘤中终止、进行端端神经缝合后以及神经挤压伤后,纤维-纤维相互作用就会发生。与在神经切断时急性形成的短暂“人工突触”不同,这种串扰形式是持久的。它的存在支持了ephaptic相互作用是神经病理生理学重要因素的假说。

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