Jankowski Marek, Gonzalez-Reyes Araceli, Noiseux Nicolas, Gutkowska Jolanta
Laboratory of Cardiovascular Biochemistry, Centre de recherche, Centre hospitalier de l'Université de Montréal and Department of Medicine, University of Montreal, Montréal, QC, Canada.
Recent Pat Cardiovasc Drug Discov. 2012 Aug;7(2):81-7. doi: 10.2174/157489012801227210.
We have demonstrated that entire oxytocin (OT) system is synthesized in the rat and human heart and this hormone is implicated in several cardiac functions including stem cells differentiation into cardiomyocytes. These observations led us to the invention of OT as an inducer of cardiomyogenesis (US20060205636A1). We also proposed the use of OT, its functional derivatives, and/or physiological precursors as well as nucleic acids capable of encoding OT as cell-differentiating and useful agents for treating or preventing diseases, such as heart diseases associated with loss of cardiomyocytes. The invention is relevant to the use of OT or OT-related compounds. OT is claimed as an inducer that promotes the differentiation of non-cardiomyocytes (e.g. stem/progenitor cells) in situ, which can be used to repair, restore or fortify damaged cardiac tissue or in cell culture in order to provide material for cell or tissue grafting in the heart. Recent reports documented the significant progress in the research on the role of OT in cardiovascular regulation. Most of the results are consistent with the postulated cardioprotective role of OT. In this review, new data are discussed in the context of the main points presented in the invention.
我们已经证明，大鼠和人类心脏中可合成完整的催产素（OT）系统，并且这种激素与包括干细胞分化为心肌细胞在内的多种心脏功能有关。这些观察结果促使我们发明了OT作为心肌生成的诱导剂（美国专利20060205636A1）。我们还提出使用OT、其功能衍生物和/或生理前体以及能够编码OT的核酸作为细胞分化剂和用于治疗或预防疾病（如与心肌细胞丧失相关的心脏病）的有用药物。本发明涉及OT或OT相关化合物的用途。OT被认为是一种诱导剂，可促进非心肌细胞（如干/祖细胞）在原位分化，可用于修复、恢复或强化受损的心脏组织，或用于细胞培养，以便为心脏的细胞或组织移植提供材料。最近的报告记录了OT在心血管调节作用研究方面的重大进展。大多数结果与OT假定的心脏保护作用一致。在本综述中，将在本发明提出的要点背景下讨论新的数据。
