Kumar Rajesh, Sharma Ashish Kumar, Saraf Shubhini A, Gupta Rajiv
Department of Pharmacognosy, Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology & Management, Lucknow, U.P., India.
J Diet Suppl. 2010 Mar;7(1):1-8. doi: 10.3109/19390210903534962.
In Ayurveda, Cissus quadrangularis Linn. is used to treat anorexia, asthma, sickle cell, colds, pain, and malaria. Aqueous C. quadrangularis extract was evaluated in vivo for its antiepileptic activity by using the maximal electroshock and isonicotinic hydrazide acid models, for its analgesic activity by using the hot plate method, and for its smooth muscle relaxant activity by using the rotarod method. Adult male Swiss mice were used for this study and animals were divided into 6 animals per group. Doses of 250 mg/kg body weight and 500 mg/kg body weight protected the mice against maximal electroshock seizure, and delayed the onset time of seizures induced by isonicotinic hydrazide acid. Prominent analgesic activity was observed using the hot plate method. The paw licking time was delayed significantly. The extract also displayed prominent smooth muscle relaxant activity. The results suggest that the aqueous extracts of C. quadrangularis roots possess anticonvulsant, analgesic, and smooth muscle relaxant properties.
在阿育吠陀医学中，四角金虎尾被用于治疗厌食、哮喘、镰状细胞病、感冒、疼痛和疟疾。通过最大电休克和异烟肼酸模型对四角金虎尾水提取物的抗癫痫活性进行了体内评估，通过热板法对其镇痛活性进行了评估，并通过旋转棒法对其平滑肌松弛活性进行了评估。本研究使用成年雄性瑞士小鼠，每组动物分为6只。250毫克/千克体重和500毫克/千克体重的剂量可保护小鼠免受最大电休克惊厥，并延迟异烟肼酸诱导的惊厥发作时间。使用热板法观察到显著的镇痛活性。舔爪时间显著延迟。该提取物还表现出显著的平滑肌松弛活性。结果表明，四角金虎尾根的水提取物具有抗惊厥、镇痛和平滑肌松弛特性。
