从臭牡丹叶中分离出的皂苷对小鼠的镇痛和抗惊厥作用。

Analgesic and anticonvulsant effects of saponin isolated from the leaves of Clerodendrum infortunatum Linn. in mice.

作者信息

Pal Dilipkumar, Sannigrahi Santanu, Mazumder Upal Kanti

机构信息

Natural Products Research Laboratory, Department of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj 757 086, Orissa, India.

出版信息

Indian J Exp Biol. 2009 Sep;47(9):743-7.

PMID:19957887

Abstract

Saponin (SN1) isolated from C. infortunatum leaves in doses of 30, 50, 75 and 100 mg/kg, ip provided 36.28, 60.47, 90.71, 100% protection respectively from writhing induced by 1.2% v/v acetic acid. In hot plate method, SN1 not only produced analgesia in mice but also potentiated the analgesic action of pentazocine and aspirin. The anticonvulsant activity was tested by leptazol-induced seizures. SN1 decreased the duration of seizures and gave protection in a dose dependent manner against leptazol-induced convulsions. The results suggest that saponin has significant analgesic and anticonvulsant effects.

摘要

从刺天茄叶中分离得到的皂苷（SN1），腹腔注射剂量为30、50、75和100mg/kg时，分别对1.2%（v/v）乙酸诱导的扭体反应提供了36.28%、60.47%、90.71%、100%的保护作用。在热板法实验中，SN1不仅能使小鼠产生镇痛作用，还能增强喷他佐辛和阿司匹林的镇痛效果。通过戊四氮诱导的惊厥来测试抗惊厥活性。SN1能缩短惊厥持续时间，并以剂量依赖的方式对戊四氮诱导的惊厥起到保护作用。结果表明，皂苷具有显著的镇痛和抗惊厥作用。