Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Clin Sci (Lond). 2012 Sep;123(5):313-21. doi: 10.1042/CS20110600.
Regular exercise can reduce the risk of CVD (cardiovascular disease). Although moderate-intensity exercise can attenuate postprandial TAG (triacylglycerol), high-intensity intermittent exercise might be a more effective method to improve health. We compared the effects of high-intensity intermittent exercise and 30 min of brisk walking on postprandial TAG, soluble adhesion molecules and markers of oxidative stress. Nine men each completed three 2-day trials. On day 1, subjects rested (control), walked briskly for 30 min (walking) or performed 5×30 s maximal sprints (high-intensity). On day 2, subjects consumed a high-fat meal for breakfast and 3 h later for lunch. Blood samples were taken at various times and analysed for TAG, glucose, insulin, ICAM-1 (intracellular adhesion molecule-1), VCAM-1 (vascular adhesion molecule-1), TBARS (thiobarbituric acid- reactive substances), protein carbonyls and β-hydroxybutyrate. On day 2 of the high-intensity trial, there was a lower (P<0.05) incremental TAG AUC (area under the curve; 6.42±2.24 mmol/l per 7 h) compared with the control trial (9.68±4.77 mmol/l per 7 h) with no differences during day 2 of the walking trial (8.98±2.84 mmol/l per 7 h). A trend (P=0.056) for a reduced total TAG AUC was also seen during the high-intensity trial (14.13±2.83 mmol/l per 7 h) compared with control (17.18±3.92 mmol/l per 7 h), walking showed no difference (16.33±3.51 mmol/l per 7 h). On day 2 of the high-intensity trial plasma TBARS and protein carbonyls were also reduced (P<0.05) when compared with the control and walking trials. In conclusion, high-intensity intermittent exercise attenuates postprandial TAG and markers of oxidative stress after the consumption of a high-fat meal.
定期运动可以降低 CVD（心血管疾病）的风险。虽然中等强度的运动可以减轻餐后 TAG（三酰甘油），但高强度间歇运动可能是改善健康更有效的方法。我们比较了高强度间歇运动和 30 分钟快走对餐后 TAG、可溶性黏附分子和氧化应激标志物的影响。9 名男性每人完成了 3 次为期 2 天的试验。第 1 天，受试者休息（对照）、快走 30 分钟（快走）或进行 5 次 30 秒最大冲刺（高强度）。第 2 天，受试者早餐和午餐后 3 小时进食高脂肪餐。在不同时间采集血样，分析 TAG、葡萄糖、胰岛素、ICAM-1（细胞间黏附分子-1）、VCAM-1（血管细胞黏附分子-1）、TBARS（硫代巴比妥酸反应物质）、蛋白质羰基和β-羟丁酸。在高强度试验的第 2 天，与对照试验（7 小时内增加 6.42±2.24mmol/l）相比，餐后 TAG AUC（曲线下面积）降低（P<0.05）（7 小时内增加 9.68±4.77mmol/l），但快走试验第 2 天没有差异（7 小时内增加 8.98±2.84mmol/l）。高强度试验中总 TAG AUC 也呈下降趋势（P=0.056）（7 小时内增加 14.13±2.83mmol/l）与对照（7 小时内增加 17.18±3.92mmol/l）相比，快走没有差异（7 小时内增加 16.33±3.51mmol/l）。在高强度试验的第 2 天，与对照和快走试验相比，血浆 TBARS 和蛋白质羰基也降低（P<0.05）。总之，高强度间歇运动可减轻高脂肪餐后的餐后 TAG 和氧化应激标志物。
