Turgut Abdulkadir, Demirci Oya, Demirci Elif, Uludoğan Mehmet
Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.
J Prenat Med. 2010 Jul;4(3):51-8.
To examine and to compare postpartum maternal and neonatal complications and morbidities in women with HELLP syndrome (HELLP group) and women with severe preeclampsia without HELLP syndrome (severe preeclamptic group).
In this retrospective study, 111 patients in the HELLP group were matched with 467 patients in the severe preeclamptic group according to maternal and neonatal complications and morbidities.
The rate of transfusion of blood products and acute renal failure was significantly greater in women with HELLP syndrome. One maternal mortality (0.9 % ) was found in women withHELLP syndrome, and no maternal mortality in women in severe preeclamptic group a. There were significant differences between the HELLP group and the severe preeclamptic group in neonatal mortality and morbidity. It was found that HELLP syndrome cases had significantly lower gestational age and fetal bodyweight. The simultaneous presence of HELLP syndrome and preeclampsia, along with oliguria, ascites, thrombocytopenia, elevated liver enzymes and caesarean delivery, was associated with post-partum complications.
This study shows that maternal and neonatal morbidity and mortality are increased in pregnancies complicated by severe preeclampsia with HELLP syndrome. Neonatal mortality and morbidity appear to be influenced primarily by gestational age at delivery.
研究并比较伴有HELLP综合征的产妇(HELLP组)和伴有重度子痫前期但无HELLP综合征的产妇(重度子痫前期组)产后的母婴并发症及发病情况。
在这项回顾性研究中,根据母婴并发症及发病情况,将111例HELLP组患者与467例重度子痫前期组患者进行匹配。
HELLP综合征患者的血液制品输注率和急性肾衰竭发生率显著更高。HELLP综合征患者中有1例产妇死亡(0.9%),重度子痫前期组无产妇死亡。HELLP组与重度子痫前期组在新生儿死亡率和发病率方面存在显著差异。发现HELLP综合征病例的孕周和胎儿体重显著更低。HELLP综合征与子痫前期同时存在,以及少尿、腹水、血小板减少、肝酶升高和剖宫产,与产后并发症相关。
本研究表明,重度子痫前期合并HELLP综合征的妊娠会增加母婴发病率和死亡率。新生儿死亡率和发病率似乎主要受分娩时孕周的影响。