Gallwas J, Gaschler R, Stepp H, Friese K, Dannecker C
Department of Obstetrics and Gynecology, Ludwig-Maximilians University, Munich.
Eur J Gynaecol Oncol. 2012;33(1):37-41.
To compare two different systems for optical coherence tomography for the diagnosis of cervical dysplasia and to assess potential benefits of three-dimensional imaging.
OCT images were taken from unsuspicious and suspicious areas of fresh conisation specimens using two different imaging systems, one with the capability to produce three-dimensional images. All OCT images were separately evaluated by two blinded investigators based on a 6-grade classification (normal, inflammation, CIN 1, CIN 2, CIN 3, squamous carcinoma) and later compared to the corresponding histology. Sensitivity and specificity of OCT in detecting cervical dysplasia were determined.
OCT images using both OCT systems were taken from 46 sites in ten conisation specimens and later compared to the corresponding histology. CIN lesions were diagnosed correctly by the two-dimensional OCT system with a sensitivity and specificity of 91% and 78% accordingly. Using the three-dimensional system sensitivity and specificity were 82% and 86% accordingly.
Both OCT systems used were highly sensitive in identifying cervical intraepithelial neoplasia. Despite technical problems experienced in the present series, we believe that three-dimensional imaging has the potential to further improve the accuracy of optical coherence tomography.
比较两种不同的光学相干断层扫描系统用于诊断宫颈发育异常，并评估三维成像的潜在益处。
使用两种不同的成像系统，从新鲜锥形切除标本的无异常和可疑区域获取光学相干断层扫描（OCT）图像，其中一种系统具备生成三维图像的能力。所有OCT图像由两名不知情的研究人员分别基于六级分类（正常、炎症、宫颈上皮内瘤变1级、2级、3级、鳞状细胞癌）进行评估，随后与相应的组织学结果进行比较。确定OCT检测宫颈发育异常的敏感性和特异性。
使用两种OCT系统从十个锥形切除标本的46个部位获取了OCT图像，随后与相应的组织学结果进行比较。二维OCT系统诊断宫颈上皮内瘤变病变的敏感性和特异性分别为91%和78%。使用三维系统时，敏感性和特异性分别为82%和86%。
所使用的两种OCT系统在识别宫颈上皮内瘤变方面均具有高度敏感性。尽管本系列研究中遇到了技术问题，但我们认为三维成像有潜力进一步提高光学相干断层扫描的准确性。
