Kortsmit Jeroen, Davies Neil H, Miller Renee, Macadangdang Jesse R, Zilla Peter, Franz Thomas
a Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town , Cape Town , South Africa.
Comput Methods Biomech Biomed Engin. 2013;16(11):1185-95. doi: 10.1080/10255842.2012.656611. Epub 2012 Mar 22.
An emerging therapy to limit adverse heart remodelling following myocardial infarction (MI) is the injection of polymers into the infarcted left ventricle (LV). In the few numerical studies carried out in this field, the definition and distribution of the hydrogel in the infarcted myocardium were simplified. In this computational study, a more realistic biomaterial distribution was simulated after which the effect on cardiac function and mechanics was studied. A validated finite element heart model was used in which an antero-apical infarct was defined. Four infarct models were created representing different temporal phases in the progression of a MI. Hydrogel layers were simulated in the infarcted myocardium in each model. Biomechanical and functional improvement of the LV was found after hydrogel inclusion in the ischaemic models representing the early phases of MI. In contrast, only functional but no mechanical restitution was shown in the scar model due to hydrogel presence.
一种限制心肌梗死（MI）后不良心脏重塑的新兴疗法是将聚合物注入梗死的左心室（LV）。在该领域进行的少数数值研究中，水凝胶在梗死心肌中的定义和分布被简化了。在这项计算研究中，模拟了更符合实际的生物材料分布，之后研究了其对心脏功能和力学的影响。使用了一个经过验证的有限元心脏模型，其中定义了前尖部梗死。创建了四个梗死模型，代表MI进展中的不同时间阶段。在每个模型的梗死心肌中模拟了水凝胶层。在代表MI早期阶段的缺血模型中加入水凝胶后，发现LV的生物力学和功能得到改善。相比之下，在瘢痕模型中，由于水凝胶的存在，仅显示了功能恢复，而没有力学恢复。
