Pastore G, Krengli M, Gambaro G, Turri L, Pisani P
Divisione Clinicizzata di Radioterapia Oncologica, Ospedale Maggiore, Novara.
Radiol Med. 1990 Oct;80(4):510-3.
This study was aimed at retrospectively analyzing the incidence and severity of the complications occurred in 141 patients affected with nasopharyngeal carcinomas treated with exclusive radiotherapy from 1960 to 1986. The acute complications were analyzed (85/141 grade II-III mucositis which generally came to a complete remission) which occurred during and immediately after radiation treatment. The late damage was then studied which occurred in 74/141 patients (52.5%) and which may worsen patients' quality of life. Finally, the incidence and severity of damage were correlated with some parameters: sex, age, performance status, risk factors (tabagism, alcoholism, diabetes), stage, total dose, fractionation, and processing techniques for treatment planning.
本研究旨在回顾性分析1960年至1986年间接受单纯放疗的141例鼻咽癌患者并发症的发生率和严重程度。分析了放疗期间及放疗后即刻出现的急性并发症（85/141例II-III级黏膜炎，通常完全缓解）。然后研究了74/141例患者（52.5%）出现的晚期损伤，这些损伤可能会降低患者的生活质量。最后，将损伤的发生率和严重程度与一些参数进行了关联：性别、年龄、体能状态、危险因素（吸烟、酗酒、糖尿病）、分期、总剂量、分割方式以及治疗计划的处理技术。
