病毒进入：旧病毒，新受体。
Virus entry: old viruses, new receptors.
机构信息
Institut Pasteur, Unité de Virologie Structurale, Département de Virologie and CNRS URA 3015, 25 Rue du Dr Roux, 75724 Paris Cedex 15, France.
出版信息
Curr Opin Virol. 2012 Feb;2(1):4-13. doi: 10.1016/j.coviro.2011.12.005. Epub 2012 Jan 2.
Abstract
The long-sought entry receptors for rubella, sindbis and respiratory syncytial viruses (RV, SV and RSV), together with the missing measles virus (MV) receptor for infection of epithelial cells, were identified in 2011. These have been major developments in the field of virus entry. In addition, 2011 was rich in new information about the interactions of MV, RSV and phleboviruses with DC-SIGN during infection of dendritic cells, a crucial step allowing the virus to breach the epithelial barrier and gain access to the lymph nodes. This faciliates dissemination to susceptible tissues where it can develop a vigorous and sustained replication, to eventually target specific organs from which it can propagate into the environment and efficiently infect new hosts, closing the merry-go-round of the virus cycle.
摘要
2011 年，人们终于找到了风疹、辛德比斯和呼吸道合胞病毒（RV、SV 和 RSV）长期以来寻找的进入受体，以及缺失的麻疹病毒（MV）进入上皮细胞的受体。这些是病毒进入领域的重大进展。此外，2011 年还提供了大量关于麻疹病毒、呼吸道合胞病毒和黄病毒在感染树突状细胞时与 DC-SIGN 相互作用的新信息，这是一个关键步骤，允许病毒突破上皮屏障并进入淋巴结。这有助于病毒传播到易感组织，在那里它可以进行强烈和持续的复制，最终靶向特定器官，从那里它可以传播到环境中，并有效地感染新的宿主，从而完成病毒循环的循环。
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本文引用的文献
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Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus.肿瘤细胞标志物 PVRL4（神经节苷脂 4）是麻疹病毒的上皮细胞受体。
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Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts.天然抗性相关巨噬细胞蛋白是辛德毕斯病毒在昆虫和哺乳动物宿主中的细胞受体。
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