Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States.
Curr Opin Virol. 2012 Feb;2(1):96-102. doi: 10.1016/j.coviro.2011.11.005. Epub 2011 Dec 11.
The advent of molecular techniques and their increasingly widespread use in public health laboratories and research studies has transformed the understanding of the burden of norovirus. Norovirus is the most common cause of community-acquired diarrheal disease across all ages, the most common cause of outbreaks of gastroenteritis, and the most common cause of foodborne disease in the United States. They are a diverse group of single-stranded RNA viruses that are highly infectious and stable in the environment; both symptomatic and asymptomatic infections are common. Through shedding in feces and vomit, norovirus can be transmitted directly through an array of routes: person-to-person, food or the environment. The relative importance of environmental transmission of virus is yet to be fully quantified but is likely to be substantial and is an important feature that complicates control.
分子技术的出现及其在公共卫生实验室和研究中的日益广泛应用,改变了人们对诺如病毒负担的认识。诺如病毒是所有年龄段人群中最常见的社区获得性腹泻病病原体,是引起食源性疾病暴发的最常见原因,也是美国最常见的食源性疾病病原体。它是一组具有高度传染性和环境稳定性的单链 RNA 病毒,有症状和无症状感染都很常见。通过粪便和呕吐物排出,诺如病毒可以通过多种途径直接传播:人与人之间、食物或环境。病毒的环境传播的相对重要性尚未得到充分量化,但很可能相当大,这是一个复杂控制的重要特征。