美国一名接种疫苗的透析患者乙肝病毒（HBV）表面抗原假阴性但HBV DNA水平高
False-negative hepatitis B virus (HBV) surface antigen in a vaccinated dialysis patient with a high level of HBV DNA in the United States.
作者信息
Foy Matthew C, Thio Chloe L, Hwang Hyon S, Saulynas Melissa, Hamilton James P, Fine Derek M, Atta Mohamed G
机构信息
Medicine, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
出版信息
Clin Vaccine Immunol. 2012 May;19(5):820-2. doi: 10.1128/CVI.05696-11. Epub 2012 Mar 21.
Abstract
Screening with hepatitis B surface antigen (HBsAg) is highly recommended for at-risk individuals. Mutations in the HBsAg can result in an inability to detect the virus during routine screening. We describe a hemodialysis patient found to have high levels of hepatitis B virus (HBV) DNA and HBV antibody but negative HBsAg on two routine assays.
摘要
强烈建议对高危人群进行乙肝表面抗原（HBsAg）筛查。HBsAg突变可能导致在常规筛查期间无法检测到病毒。我们描述了一名血液透析患者，在两次常规检测中发现其乙肝病毒（HBV）DNA和HBV抗体水平很高，但HBsAg呈阴性。
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