医学。旧药，为阿尔茨海默病带来新希望。 - Suppr

Suppr

超能文献

Medicine. Old drug, new hope for Alzheimer's disease.

作者信息

Strittmatter Warren J

机构信息

Department of Neurology, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

Science. 2012 Mar 23;335(6075):1447-8. doi: 10.1126/science.1220725.

DOI:10.1126/science.1220725

PMID:22442467

Abstract

摘要

相似文献

Medicine. Old drug, new hope for Alzheimer's disease.医学。旧药，为阿尔茨海默病带来新希望。

Science. 2012 Mar 23;335(6075):1447-8. doi: 10.1126/science.1220725.

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".评论“载脂蛋白 E 靶向治疗迅速清除 β-淀粉样蛋白并逆转 AD 小鼠模型的缺陷”。

Science. 2013 May 24;340(6135):924-e. doi: 10.1126/science.1233937.

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".评论“ApoE 导向疗法迅速清除β-淀粉样蛋白并逆转 AD 小鼠模型的缺陷”。

Science. 2013 May 24;340(6135):924-d. doi: 10.1126/science.1234089.

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".评论“ApoE 靶向疗法快速清除β-淀粉样蛋白并逆转 AD 小鼠模型的缺陷”。

Science. 2013 May 24;340(6135):924-f. doi: 10.1126/science.1235505.

Preclinical success against Alzheimer's disease with an old drug.一种老药在对抗阿尔茨海默病方面取得临床前成功。

N Engl J Med. 2012 Aug 9;367(6):570-2. doi: 10.1056/NEJMcibr1204890.

Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".评论“ApoE 靶向疗法快速清除β-淀粉样蛋白并逆转 AD 小鼠模型的缺陷”。

Science. 2013 May 24;340(6135):924-c. doi: 10.1126/science.1235809.

Response to comments on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".对“载脂蛋白 E 靶向治疗迅速清除β-淀粉样蛋白并逆转 AD 小鼠模型的缺陷”一文的评论的回应。

Science. 2013 May 24;340(6135):924-g. doi: 10.1126/science.1234114.

ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.载脂蛋白 E 靶向治疗能迅速清除β-淀粉样蛋白并逆转 AD 小鼠模型的缺陷。

Science. 2012 Mar 23;335(6075):1503-6. doi: 10.1126/science.1217697. Epub 2012 Feb 9.

Clearing Amyloid-β through PPARγ/ApoE Activation by Genistein is a Treatment of Experimental Alzheimer's Disease.通过染料木黄酮激活PPARγ/ApoE清除β-淀粉样蛋白是治疗实验性阿尔茨海默病的一种方法。

J Alzheimers Dis. 2016;51(3):701-11. doi: 10.3233/JAD-151020.

Early Treatment Critical: Bexarotene Reduces Amyloid-Beta Burden In Silico.早期治疗至关重要：贝沙罗汀在计算机模拟中降低β-淀粉样蛋白负荷

PLoS One. 2016 Apr 13;11(4):e0153150. doi: 10.1371/journal.pone.0153150. eCollection 2016.

引用本文的文献

Genetic and clinical correlates of two neuroanatomical AI dimensions in the Alzheimer's disease continuum.阿尔茨海默病连续体中两个神经解剖人工智能维度的遗传和临床相关性。

Transl Psychiatry. 2024 Oct 5;14(1):420. doi: 10.1038/s41398-024-03121-5.

Repositioned Drugs for Inflammatory Diseases such as Sepsis, Asthma, and Atopic Dermatitis.用于治疗脓毒症、哮喘和特应性皮炎等炎症性疾病的重新定位药物。

Biomol Ther (Seoul). 2020 May 1;28(3):222-229. doi: 10.4062/biomolther.2020.001.

Current Progress on Peroxisome Proliferator-activated Receptor Gamma Agonist as an Emerging Therapeutic Approach for the Treatment of Alzheimer's Disease: An Update.过氧化物酶体增殖物激活受体 γ 激动剂作为阿尔茨海默病治疗新方法的研究进展：更新。

Curr Neuropharmacol. 2019;17(3):232-246. doi: 10.2174/1570159X16666180828100002.

Changing Trends in Computational Drug Repositioning.计算药物重新定位的变化趋势

Pharmaceuticals (Basel). 2018 Jun 5;11(2):57. doi: 10.3390/ph11020057.

Monoaminergic neuropathology in Alzheimer's disease.阿尔茨海默病中的单胺能神经病理学

Prog Neurobiol. 2017 Apr;151:101-138. doi: 10.1016/j.pneurobio.2016.04.001. Epub 2016 Apr 12.

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene Xin moderate Alzheimer's disease.贝沙罗汀治疗中度阿尔茨海默病的双盲、安慰剂对照概念验证试验。

Alzheimers Res Ther. 2016 Jan 29;8:4. doi: 10.1186/s13195-016-0173-2.

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies.阿尔茨海默病及其他tau蛋白病中的tau蛋白过度磷酸化与聚集，以及可能的神经保护策略。

Biomolecules. 2016 Jan 6;6(1):6. doi: 10.3390/biom6010006.

Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils.二聚体双（庚基）-Cognitin通过抑制Aβ纤维形成和已形成纤维的解聚来阻断阿尔茨海默病β-淀粉样蛋白的神经毒性。

CNS Neurosci Ther. 2015 Dec;21(12):953-61. doi: 10.1111/cns.12472. Epub 2015 Oct 28.

Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.淀粉样蛋白清除蛋白及其在阿尔茨海默病中的表观遗传调控作为治疗靶点。

Front Aging Neurosci. 2014 Sep 17;6:235. doi: 10.3389/fnagi.2014.00235. eCollection 2014.

Brain metabolite clearance: impact on Alzheimer's disease.脑代谢物清除：对阿尔茨海默病的影响

Metab Brain Dis. 2014 Sep;29(3):553-61. doi: 10.1007/s11011-014-9527-2. Epub 2014 Mar 25.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验