苯乙哌啶酮对免疫应激动物的心理免疫调节作用。

Psychoimmunomodulatory effect of phenotropil in animals with immune stress.

作者信息

Samotrueva M A, Tyurenkov I N, Teplyi D L, Serezhnikova T K, Khlebtsova E B

机构信息

Department of Pharmacognosy with the Course of Pharmaceutical Technology and Biotechnology, Astrakhan State Medical Academy, Russian Ministry of Health, Russia.

出版信息

Bull Exp Biol Med. 2011 May;151(1):51-4. doi: 10.1007/s10517-011-1257-4.

DOI:10.1007/s10517-011-1257-4

PMID:22442801

Abstract

We studied the effect of phenotropil (25 mg/kg intraperitoneally, 5 days) on the immune and psychoemotional state of Wistar rats with LPS-induced immune stress. Hyperactivity of the immune system in animals after treatment with Pseudomonas aeruginosa LPS (100 μg/kg intraperitoneally, 3 days) manifested in a significant increase in the delayed-type hypersensitivity index, antibody titer in the reaction of passive hemagglutination, and phagocytic activity of peripheral blood neutrophils. Locomotor, orientation, and exploratory activities were reduced, while anxiety increased in animals with immune stress. Phenotropil exhibited the psychoimmunomodulatory effect under these conditions, which manifested in prevention of anxiety and fear response, increase in horizontal locomotion and exploratory behavior, and improvement of immunoreactivity.

摘要

我们研究了苯乙哌啶（25毫克/千克腹腔注射，共5天）对脂多糖诱导的免疫应激的Wistar大鼠免疫和心理情绪状态的影响。用铜绿假单胞菌脂多糖（100微克/千克腹腔注射，共3天）处理后，动物免疫系统的亢进表现为迟发型超敏反应指数显著增加、被动血凝反应中的抗体滴度以及外周血中性粒细胞的吞噬活性增加。免疫应激动物的运动、定向和探索活动减少，而焦虑增加。在这些条件下，苯乙哌啶表现出心理免疫调节作用，表现为预防焦虑和恐惧反应、增加水平运动和探索行为以及改善免疫反应性。