Rhim Jung-Woo, Go Eun-Ji, Lee Kyung-Yil, Youn You-Sook, Kim Myung-Sook, Park Sun Hee, Kim Ji-Chang, Kang Jin-Han
Departments of Pediatrics, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Republic of Korea.
Int Arch Med. 2012 Mar 26;5(1):13. doi: 10.1186/1755-7682-5-13.
In 2009, there was an influenza pandemic in South Korea. The aim of this study was to evaluate the epidemiological, clinical and laboratory characteristics of this infection in children and adults.
We evaluated the epidemiologic characteristics of patients infected with the 2009 H1N1 influenza A virus (4,463 patients, age range from 2 mo to 86 y), and the clinical and laboratory findings of 373 inpatients (80/217 children, ≤ 15 y, had pneumonia and 36/156 adults, > 16 y, had pneumonia) in a single hospital during the epidemic.
The majority of infected patients (94%) were less than 40 y, and greater than 90% of cases occurred during a two-month period. The rates of admission and pneumonia were 8.4% (373/4,463) and 2.5% (116/4,463), respectively. The rates of admission and pneumonia, total duration of fever, the frequency of underlying diseases, and the values of C-reactive protein and erythrocyte sedimentation rate tended to increase as age increased; highest rates were found in the ≥ 65 y group. Pneumonia was founded more boys than girls in children, but more female than male in adults. The adult patients with pneumonia had higher leukocyte counts with lower lymphocyte differentials than the group without pneumonia, as shown in children group.
Our results suggest that the immunologic reaction to viral insults may be associated with age, sex and underlying diseases, and that unknown herd immunity may affect populations. The patients with underlying diseases, especially in older patients may have immunologic insufficiency that is associated with immunologic consumption by the underlying diseases.
2009年韩国发生了甲型H1N1流感大流行。本研究的目的是评估儿童和成人感染这种病毒后的流行病学、临床和实验室特征。
我们评估了2009年甲型H1N1流感病毒感染患者的流行病学特征（4463例患者，年龄范围从2个月至86岁），以及疫情期间一家医院373例住院患者（80例/217例儿童，≤15岁，患有肺炎；36例/156例成人，>16岁，患有肺炎）的临床和实验室检查结果。
大多数感染患者（94%）年龄小于40岁，超过90%的病例发生在两个月内。入院率和肺炎发生率分别为8.4%（373/4463）和2.5%（116/4463）。入院率、肺炎发生率、发热总时长、基础疾病发生率、C反应蛋白和红细胞沉降率的值往往随着年龄的增长而增加；≥65岁组的发生率最高。儿童肺炎患者中男孩多于女孩，但成人中女性多于男性。与儿童组情况一样，成人肺炎患者的白细胞计数较高，淋巴细胞分类较低。
我们的结果表明，对病毒攻击的免疫反应可能与年龄、性别和基础疾病有关，而且未知的群体免疫可能影响人群。患有基础疾病的患者，尤其是老年患者，可能存在免疫功能不全，这与基础疾病导致的免疫消耗有关。
