Kil Hong-Ryang, Yu Jae-Won, Lee Sung-Churl, Rhim Jung-Woo, Lee Kyung-Yil
Department of Pediatrics, Chungnam National University Hospital, School of Medicine, Chungnam National University, Daejeon, Korea.
Departments of Pediatrics, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 64 Daeheung-ro, Jung-gu, Daejeon, 34943, Republic of Korea.
Pediatr Rheumatol Online J. 2017 Aug 7;15(1):60. doi: 10.1186/s12969-017-0192-y.
Kawasaki disease (KD) becomes one of the common diseases in Korea. Changes in clinical features and laboratory findings of KD were evaluated over a period of 10 years.
We reviewed the medical records of KD patients and compared the clinical and laboratory features of two KD patient groups: those admitted from 2000 to 2004 (group A, 284 cases) and those admitted from 2010 to 2014 (group B, 331 cases).
There were a total of 615 KD patients (mean age: 29.7 months; male-to-female ratio = 1.6:1), including 228 incomplete KD patients. Incomplete KD patients had milder values in some laboratory indices. The preadmission and total fever durations were longer in group A than in group B. The proportion of incomplete KD was higher in group B, but incidence of coronary artery lesions (CALs) was lower. For laboratory indices, the C-reactive protein and follow-up platelet values were lower, and the hemoglobin and albumin values were higher in group B. The same clinical and laboratory findings were confirmed in the KD subgroups; those with the same fever duration of 5 or 6 days and same ages, those with complete KD, and those with incomplete KD in the two different time periods.
Our findings suggest that clinical features of KD tend to be milder over time and manifest in a higher incidence of incomplete KD, lower incidence of CALs, and less severe laboratory findings in recent KD patients in Korea compared with their historic counterparts.
川崎病（KD）已成为韩国的常见疾病之一。我们评估了10年间KD临床特征和实验室检查结果的变化。
我们回顾了KD患者的病历，并比较了两组KD患者的临床和实验室特征：2000年至2004年入院的患者（A组，284例）和2010年至2014年入院的患者（B组，331例）。
共有615例KD患者（平均年龄：29.7个月；男女比例=1.6:1），其中包括228例不完全KD患者。不完全KD患者的一些实验室指标值较轻。A组入院前和总发热持续时间比B组更长。B组不完全KD的比例更高，但冠状动脉病变（CALs）的发生率更低。对于实验室指标，B组的C反应蛋白和随访血小板值较低，血红蛋白和白蛋白值较高。在KD亚组中也证实了相同的临床和实验室结果；在两个不同时间段内，发热持续时间相同为5或6天且年龄相同的患者、完全KD患者以及不完全KD患者。
我们的研究结果表明，随着时间的推移，KD的临床特征趋于更温和，表现为不完全KD的发生率更高、CALs的发生率更低，并且与过去的患者相比，韩国近期KD患者的实验室检查结果不那么严重。
