Department of Biological Sciences and Geology, Queensborough Community College, Bayside, NY 11364, USA.
Med Clin North Am. 2012 Mar;96(2):257-68. doi: 10.1016/j.mcna.2012.01.006. Epub 2012 Feb 14.
Thyroid hormone has profound effects on the heart and cardiovascular system. This article describes the cellular mechanisms by which thyroid hormone acts at the level of the cardiac myocyte and the vascular smooth muscle cell to alter phenotype and physiology. Because it is well established that thyroid hormone, specifically T(3), acts on almost every cell and organ in the body, studies on the regulation of thyroid hormone transport into cardiac and vascular tissue have added clinical significance. The characteristic changes in cardiovascular hemodynamics and metabolism that accompany thyroid disease states can then be best understood at the cellular level.
甲状腺激素对心脏和心血管系统有深远的影响。本文描述了甲状腺激素在心肌细胞和血管平滑肌细胞水平上发挥作用的细胞机制，从而改变表型和生理学。由于已经确定甲状腺激素，特别是 T3，作用于体内几乎每个细胞和器官，因此对甲状腺激素向心脏和血管组织转运的调节的研究增加了临床意义。伴随甲状腺疾病状态的心血管血液动力学和代谢的特征变化可以在细胞水平上得到最好的理解。
