对于MutY来说，一切都与原始基因有关。
For MutY, it's all about the OG.
作者信息
Sobol Robert W
机构信息
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
出版信息
Chem Biol. 2012 Mar 23;19(3):313-4. doi: 10.1016/j.chembiol.2012.03.002.
Abstract
MutY and its human ortholog, MUTYH, repair a specific form of DNA damage: adenine mis-paired with the oxidatively modified form of deoxyguanosine, 8-oxo-7,8-dihydro-2'-deoxyguanosine. In a recent issue of Chemistry & Biology, Brinkmeyer et al. utilized mutant forms of MutY to reveal the critical residues in MutY that are required for this selectivity and specificity.
摘要
MutY及其人类同源蛋白MUTYH修复一种特定形式的DNA损伤：腺嘌呤与脱氧鸟苷的氧化修饰形式8-氧代-7,8-二氢-2'-脱氧鸟苷错配。在最近一期的《化学生物学》杂志上，布林克迈耶等人利用MutY的突变形式揭示了MutY中实现这种选择性和特异性所需的关键残基。
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