Neuroinflammation Research Center, Department of Neuroscience, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
J Neuroimmunol. 2012 May 15;246(1-2):1-9. doi: 10.1016/j.jneuroim.2012.02.016. Epub 2012 Mar 22.
The innate immune system is a crucial component of inflammatory reactions, while the central nervous system (CNS) is the most vulnerable site of the body to inflammatory tissue injury. Neuroinflammatory brain pathologies are disorders in which the CNS is threatened by its own immune system. Chemokine receptor CXCR2 and its ligands have been implicated in several neuroinflammatory brain pathologies, as well as in neutrophil recruitment and in the developmental positioning of neural cells. This review focuses on the basics of CXCR2, its regulating role in bone marrow neutrophil recruitment, oligodendrocyte progenitor cell positioning and neural repair mechanisms, as well as its diverse roles in neuroinflammatory brain pathologies.
先天免疫系统是炎症反应的一个关键组成部分，而中枢神经系统 (CNS) 是身体对炎症性组织损伤最易受影响的部位。神经炎症性脑病理是指 CNS 受到自身免疫系统威胁的疾病。趋化因子受体 CXCR2 及其配体已被牵连到几种神经炎症性脑病理中，以及中性粒细胞的募集和神经细胞的发育定位中。这篇综述重点介绍了 CXCR2 的基础知识、其在骨髓中性粒细胞募集、少突胶质前体细胞定位和神经修复机制中的调节作用，以及其在神经炎症性脑病理中的多种作用。
