趋化因子在健康和疾病中的作用。
Chemokines in health and disease.
机构信息
Department of Cancer Biology, Vanderbilt University, School of Medicine, USA.
出版信息
Exp Cell Res. 2011 Mar 10;317(5):575-89. doi: 10.1016/j.yexcr.2011.01.005. Epub 2011 Jan 9.
Abstract
Chemokines and their receptors play a key role in development and homeostasis as well as in the pathogenesis of tumors and autoimmune diseases. Chemokines are involved in the implantation of the early conceptus, the migration of subsets of cells during embryonic development, and the overall growth of the embryo. Chemokines also have an important role in the development and maintenance of innate and adaptive immunity. In addition, they play a significant role in wound healing and angiogenesis. When the physiological role of chemokines is subverted or chronically amplified, disease often follows. Chemokines are involved in the pathobiology of chronic inflammation, tumorigenesis and metastasis, as well as autoimmune diseases. This article reviews the role of chemokines and their receptors in normal and disease processes and the potential for using chemokine antagonists for appropriate targeted therapy.
摘要
趋化因子及其受体在发育和内稳态以及肿瘤和自身免疫性疾病的发病机制中起着关键作用。趋化因子参与早期胚胎的着床、胚胎发育过程中细胞亚群的迁移以及胚胎的整体生长。趋化因子在先天和适应性免疫的发育和维持中也具有重要作用。此外，它们在伤口愈合和血管生成中也起着重要作用。当趋化因子的生理作用被颠覆或慢性放大时，往往会引发疾病。趋化因子参与慢性炎症、肿瘤发生和转移以及自身免疫性疾病的病理生物学过程。本文综述了趋化因子及其受体在正常和疾病过程中的作用，以及使用趋化因子拮抗剂进行适当靶向治疗的潜力。
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